valproicacid相关论文
目的:研究拉莫三嗪联合丙戊酸治疗癫痫的临床效果.方法:根据治疗方案不同,将88例癫痫患者分为44例/组.对照组予以丙戊酸治疗,观察......
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Effects of Sustained VPA-Release Conduits on Peripheral Nerve Regeneration:An In Vitro and In Vivo S
Background: Despite the numerous advances of artificial nerve conduits,autologous nerve grafts remain the most effective......
Glucocorticoid medication is one of the most common causes of atraumatic osteonecrosis of the femoral head(ONFH),and val......
Reversal of decreased hippocampal protein serine/threonine kinases by modulating pineal hormone in a
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Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MAPK phosphatase
Aim: Inflammation and vascular perturbations are increasingly implicated in the pathogenesis of neurodegenerative diseas......
BETWEEN 2001 AND 2006,ANALYSIS FOR THE BLOOD CONCENTRATION OF ANTI-EPILEPTIC DRUGS IN TIAN TAN HOSPI
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Background: Valproic acid(VPA),an old antiepileptic drug,is advised as the first line therapy for absent epilepsy.Howeve......
The Effect of a Novel HDAC3-selective Inhibitor on Osteogenic Induction of Human Adipose Derived Ste
Purpose: Histone deacetylases(HDAC)are regarded as important defining the epigenetic program during the lineage differen......
Development and validation of a simple HPLC-UV method for the quantification of valproic acid in ser
Objective:To develop and validate a simple HPLC-UV method for the quantification of valproic acid in serum used for TDM.......
A transiently reduced cell proliferation by valproic acid in the telencephalic brain of zebrafish la
Valproic acid (VPA) is used as an antiepileptic drug or mood stabilizer.Recent studies have shown that exposure to VPA d......
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Di
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1例1岁4个月男孩因癫痫口服丙戊酸钠口服液2.5 ml、2次/d，升血调元汤6 ml、2次/d和五维葡钙口服液3 ml、2次/d治疗。用药第13天，患儿......
目的:探讨尿苷二磷酸葡糖醛酸转移酶(UGT)1A4 142T>G基因多态性和丙戊酸(VPA)血药浓度对我国南方汉族癫痫儿童体内拉莫三嗪(LTG)血......
目的 探讨丙戊酸钠(VPA)对不同性别APP/PS1双重转基因阿尔茨海默病(AD)模型小鼠的空间学习记忆能力及脑内老年斑(SP)的沉积的影响.......
目的系统评价抗癫痫药物丙戊酸和托吡酯单药使用对体质量和血浆瘦素水平的影响。方法通过计算机检索Cochrane图书馆、PubMed、EMBA......
Effect of topiramate and traditional antiepileptic drugs on pituitary-sexual gland axis in adult mal
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Effects of topiramate versus other antiepileptic drugs on the cognitive function of patients with ep
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Effect of valproic acid on endogenous neural stem cell proliferation in a rat model of spinal cord i
BACKGROUND: Valproic acid has been reported to decrease apoptosis, promote neuronal differentiation of brain-derived neu......
目的分析拉莫三嗪联合小剂量丙戊酸钠治疗新诊断癫痫的临床效果。方法选取新诊断癫痫患者90例，采用随机数字表法分为对照组、观察组......
目的 探讨不同浓度丙戊酸钠对人消化系统肝癌SMMOL/LC-7721细胞株及胰腺癌PaTu8988细胞株细胞增殖和细胞周期的影响.方法 将肝癌SM......
目的 检测服用丙戊酸钠治疗的癫痫患儿体内中性粒细胞活性的改变,并探讨其相关的临床意义.方法 收集服用丙戊酸钠治疗的癫痫患儿34......
目的建立丙戊酸钠(valproic acid,VPA)孤独症动物模型,观察核转录因子κB和小清蛋白阳性神经元在VPA孤独症模型鼠海马CA1区的表达,......
目的 研究丙戊酸(VPA)对致死性烫伤大鼠心肌的保护作用及机制.方法 78只雄性SD大鼠按随机数字表法分为假烫组(n=10)、假烫+VPA组(n......
目的探讨丙戊酸钠（VPA）对致死性烫伤大鼠肠屏障的保护作用及其机制。方法清洁级雄性SD大鼠40只，按随机数字表法分为假烫（Sham）+生理盐水......
目的建立一种测定人血浆中丙戊酸钠游离浓度的中空纤维离心超滤-高效液相色谱（HPLC）方法。方法血浆样本经中空纤维离心超滤技术预处......
目的：探讨Wnt/β-catenin信号通路对孤独症发生过程中重复呆板样行为的影响。方法利用丙戊酸（valproic acid，VPA）孤独症动物模型，检测了......
1例41岁男性患者胶质母细胞瘤切除术后出现癫痫，给予奥卡西平(初始剂量为0.3 g、2次/d，后加至0.6 g、2次/d)和丙戊酸钠(500 mg、1次/......
2-丙基-2-戊烯酸(2-ene-VPA)为丙戊酸钠在体内经线粒体β氧化产生的代谢产物，具有抗癫痫活性和镇静作用，同时具有一定的肝毒性和神经......
目的 比较碳青霉烯类抗菌药比阿培南与美罗培南对丙戊酸(VPA)血药浓度的影响。方法 收集2008年1月至2013年12月在苏州市立医院住院......
Liquid chromatography-tandem mass spectrometry method for simultaneous determination of valproic aci
A simple and high throughput method was developed and validated for simultaneous determination of valproic acid and its ......
1例58岁男性患者因癫痫发作持续静脉泵入丙戊酸钠33.6 mg/h，连续用药3 d。7 d后患者行左颞叶病灶切除术，手术次日PLT从入院时的242×......
1例56岁男性患者脑出血手术后为预防癫痫口服丙戊酸钠缓释片0.5 g/d。用药36 d复查血常规，WBC 3.3×109/L，RBC 3.2×1012/L，Hb 100 g/......
目的探讨儿童丙戊酸钠(VPA)相关高血氨脑病(VHE)的临床特点。方法检索山西医科大学第一医院病案数字化综合管理系统，收集2006年7月......
1例20岁男性患者因手足徐动症服用丙戊酸钠缓释片500 mg、2次/d，20 d后全身出现弥漫性鲜红色斑块，压之褪色，皮温升高，面部肿胀，头颈部浅......
1例45岁、有10余年吸毒史的男性患者单次自行服用丙戊酸钠缓释片96片(48 g)及齐拉西酮胶囊20余粒(>400 mg)后出现昏迷，呼之不应，家属......
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via t
Lipid metabolism reprogramming is now accepted as a new hallmark of cancer.Hence,target-ing the lipogenesis pathway may ......
目的 研究中药单体冬凌草甲素(ORI)联合组蛋白去乙酰化酶抑制剂丙戊酸钠(VPA)诱导急性早幼粒白血病细胞株HL-60凋亡,探讨其应用于......
目的 研究组蛋白脱乙酰化酶(HDAC)抑制剂丙戊酸钠(VPA)对白血病细胞系Kasnmi-1细胞周期的影响并探讨其分子机制.方法 不同浓度VPA......
目的 观察丙戊酸钠(VPA)充填导管对缺损外周神经再生的促进作用.方法 通过建立大鼠坐骨神经缺损模型.用硅胶管(1 cm)进行缺损神经......
Effects of topiramate versus other antiepileptic drugs on the cognitive function of patients with ep
BACKGROUND: Only very large dose of topiramate has neurotoxicity, indicating that topiramate has low neurotoxicity and h......
Effect of topiramate and traditional antiepileptic drugs on pituitary-sexual gland axis in adult mal
BACKGROUND: Some reports indicate that traditional antiepileptic drugs can cause a certain effect on reproductive endocr......
目的：探讨经典Wnt信号通路在孤独症发病中的作用。方法：利用丙戊酸孤独症大鼠模型，检测经典Wnt信号通路信号分子在孤独症大鼠前额叶皮......
Valproic acid （VPA） is one of the most prescribed drugsin children with newly diagnosed epilepsy. Weightgain and obesity h......
